技術情報・文献記事




The full recovery of mice (Mus Musculus C57BL/6 strain) from virus-induced sarcoma after treatment with a complex of DDMC delivery system and sncRNAs
Non-coding RNA Research, 2019, In Press
https://www.sciencedirect.com/science/article/pii/S2468054018301045



A robust control system for targeting melanoma by a supermolecular DDMC/paclitaxel complex
Integrative Biology, 2018,10, 549-554
https://pubs.rsc.org/en/content/articlelanding/2018/ib/c8ib00071a/unauth#!divAbstract



Supermolecular drug challenge to overcome drug resistance in cancer cells
Drug Discovery Today, 2018
https://www.sciencedirect.com/science/article/pii/S1359644617305718



The Disappeared Cancer Cell by SncRNAs: Application of DDMC Vector/SncRNAs Complex for Transformation of Cancer Cells into Non-cancerous Cells
Journal of Nanomedicine & Biotherapeutic Discovery, 2018, 8:1
https://www.longdom.org/open-access/the-disappeared-cancer-cell-by-sncrnas-application-of-ddmc-vectorsncrnas-complex-for-transformation-of-cancer-cells-into-noncancer-2155-983X-1000e147.pdf



Small non-coding RNAs as regulators of structural evolution and carcinogenesis.
Non-coding RNA Research, Volume 2, Issue 2, June 2017, Pages 88-92
https://www.sciencedirect.com/science/article/pii/S2468054017300215



Toxicity and Transfection Efficiency of New Non-Viral Delivery Systems for Small Non-Coding RNAs: Amphiphilic Poly(N-Vinylpyrrolidone) and Diethylaminoethyl-Dextran-Methacrylic Acid Methyl Ester Copolymer
Advanced Science, Engineering and Medicine, 9, (6), 426-431(2017)
https://www.ingentaconnect.com/content/asp/asem/2017/00000009/00000005/art00010



Joint Action of the Nano-sized System of Small Non-coding RNAs with DDMC Vector and Recombinant IL-7 Reprograms A-549 Lung Adenocarcinoma Cells into CD4+ Cells.
Immunotherapy (Los Angel) 3: 137. doi:10.4172/2471-9552.1000137 (2017)
https://www.omicsonline.org/open-access/joint-action-of-the-nanosized-system-of-small-noncoding-rnas-with-ddmcvector-and-recombinant-il7-reprograms-a549-lung-adenocarcino-2471-9552-1000137.php?aid=87469 target=



Complex of Small Non-coding RNAs piR-30074 and Antago-miR-155 and miR-125b with DDMC Carrier Transforms Girardi Heart Cells into CD4+ Cells
Journal of Cancer and Tumor International, ISSN: 2454-7360,Vol.: 4, Issue.: 4 (2016)



DEAE-デキストラン-MMAグラフト共重合体をホストとして用い、ゲストのパクリタキセルと成る、超分子複合体(DDMC/PTX)の開発および抗癌メカニズムの研究 第6回 癌・炎症と抗酸化研究会 大分市、ホルトホール大分 2015年11月14日
CIA2015-YOnishi.pdf



   
新聞掲載: 大分合同新聞に弊社開発のDDS製剤 (DDMC/PTX)の記事が掲載されました。
「 新タイプの抗がん剤 大分大・愛知の企業が開発 」
2015年2月21日 大分合同新聞 朝刊 P18    



Medicinal facilities to B16F10 melanoma cells for distant metastasis control with a supramolecular complex by DEAE-dextran-MMA copolymer/paclitaxel
Drug Delivery and Translational Research. 5:38-50(2015)
https://link.springer.com/article/10.1007/s13346-014-0213-z#abbreviations



Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl-dextran-MMA graft copolymer and paclitaxel used as an artificial enzyme
Beilstein J. Nanotechnol. 2014, 5, 2293-2307. (2014)
https://www.beilstein-journals.org/bjnano/articles/5/238



Allosteric Facilities as Artificial Enzymes to Cancer Cell of Supramolecular Complex by Polymer/Anti-Cancer Agents
J Nanomedine Biotherapeutic Discov 4:e127 (2014)
https://www.longdom.org/open-access/allosteric-facilities-as-artificial-enzymes-to-cancer-cell-of-supramolecular-complex-by-polymeranticancer-agents-2155-983X.1000e127.pdf



DEAE-デキストラン共重合体をホストとして用い、ゲストのパクリタキセルと成る、超分子複合体: その人工酵素、抗癌メカニズム
大分大学工学部研究報告, 第61 号:17-30,2014.
kenkyu-ronbun-B61.pdf



Intratumoral gene therapy versus intravenous gene therapy for distant metastasis control with 2-Diethylaminoethyl-Dextran Methyl Methacrylate Copolymer Non-Viral Vector-p53
Gene Therapy 21, 158-167 (February 2014)
https://www.nature.com/articles/gt201368l



Dextran Graft Copolymers: Synthesis, Properties and Applications
Polysaccharide Based Graft Copolymers pp 205-269, Springer(2013)
https://link.springer.com/chapter/10.1007/978-3-642-36566-9_6



Supramolecular Targeting of B16F10 Melanoma Cells With Nanoparticles Consisting of a DEAE-Dextran-MMA Copolymer-Paclitaxel Complex
J Nanomed Biotherapeut Discov 2:5(2012)
https://www.longdom.org/open-access/supramolecular-targeting-of-b16f10-melanoma-cells-with-nanoparticles-consisting-of-a-deae-dextran-mma-copolymer-paclitaxel-complex-in-vivo-and-in-vitro-2155-983X.1000109.pdf



Supramolecular Facilities to Melanoma Cells B16F10 with Nanoparticles of a DEAE-Dextran-MMA Copolymer-Paclitaxel Complex
J Nanomed Nanotechol S:5(2012)
https://www.longdom.org/open-access/supramolecular-facilities-to-melanoma-cells-b16f10-with-nanoparticles-of-a-deae-dextran-mma-copolymer-paclitaxel-complex-2157-7439.S5-002.pdf



Mechanism of the Introduction of Exogenous Genes into Cultured Cells Using DEAE-Dextran-MMA Graft Copolymer as a Non-Viral Gene Carrier. II. Its Thixotropy Property
J Nanomedic Nanotechnol 2:105(2011)
https://www.longdom.org/abstract/mechanism-of-the-introduction-of-exogenous-genes-into-cultured-cells-using-deaedextranmma-graft-copolymer-as-a-nonviral--31994.html



DEAE-デキストラン共重合体を非ウイルス性遺伝子導入キャリアーとして用いた、培養細胞への外来遺伝子導入.
大分大学工学部研究報告, 第57 号:1-8,2010. kenkyu-ronbun-57-1.pdf



DEAE-Dextran and DEAE-Dextran-MMA Graft Copolymer for Nanomedicine
Polymers Research Journal vol. 3, issue 3-4,415-453(2010)
https://www.novapublishers.com/catalog/product_info.php?products_id=24548



DEAE-DEXTRAN AND DEAE-DEXTRAN-MMA GRAFT COPOLYMER FOR NONVIRAL DELIVERY OF NUCLEIC ACIDS
Advances in Nanotechnology, Volume 3 Chapter 11(2010)
https://www.novapublishers.com/catalog/product_info.php?cPath=23_96&products_id=12644



DEAE-Dextran-MMA Graft Copolymer for Non-viral Delivery of DNA.
Jorgenson, Lene Nielson, Hanne Morck, Ed., Delivery Technologies for Biophar maceuticals,John Wiley & Sons,West Sussex UK (November 2009) https://onlinelibrary.wiley.com/doi/10.1002/9780470688397.ch17



Mechanism of Introducing ExogenousGenes into Cultured Cells Using DEAE-Dextran-MMA Graft Copolymer as Non-Viral Gene Carrier,
Molecules 14, 2669-2683 (2009).
https://www.mdpi.com/1420-3049/14/7/2669



Characteristics of 2-diethylaminoethyl(DEAE)-dextran-MMA graft copolymer as a non-viral gene carrier.
Nanomedicine: Nanotechnology, Biology, and Medicine, 3:184-191,2007.
https://www.sciencedirect.com/science/article/abs/pii/S1549963407000925



A novel vector of 2-diethylaminoethyl(DEAE)-dextran-MMA graft copolymer for no n-viral gene delivery.
第13回日本遺伝子治療学会総会、名古屋市、国際医学交流センター, 2007 Abstr.074.
abstractapp-13_Y_O_.pdf



2-diethylaminoethyl(DEAE)-Dextran-MMA graft copolymer for nonviral gene delivery vector.
Bulletin of the Research Center of Environmental Science and Technology, NIppon Bunri University (Vol.5 2006)
ddmc.pdf



Synthesis and characterization of 2-diethyl-aminoethyl-dextran-methyl methacrylate graft copolymer for nonviral gene delivery vector.
J.Appl. polym. Sci., (2005)
https://onlinelibrary.wiley.com/doi/abs/10.1002/app.21993




非ウイルス性ベクターの研究(PDF)



DDMC Vectorの特徴(PDF)



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